Immunology Research Set to Change after Study Shows T-Cell Antigen Receptors Act Alone

Researchers at TU Wien and the Vienna School of Medicine report that T-cell receptors act alone, rather than interact with one another, for effective immune signaling. Their study (“ Monomeric TCRs drive T cell antigen recognition ”) appears in  Nature Immunology .“T-cell antigen recognition requires T cell antigen receptors (TCRs) engaging MHC-embedded antigenic peptides (pMHCs) within the contact region of a T cell with its conjugated antigen-presenting cell. Despit