Immune Disorder Trigger Identified

Scientists in the U.S. have identified a promising target for treating immune system-related disorders that are associated with mutations in a gene known as GTPase of immunity-associated protein 5 (Gimap5). The researchers, led by the team of Kasper Hoebe, Ph.D., at the Cincinnati Children’s Hospital Research Foundation, used inhibitors of glycogen kinase 3β (GSK3β)—a protein that is regulated by Gimap5—to restore normal immune cell function in vitro in cells taken fr