Huntington’s Could Be Slowed by Blocking Aggregation Mechanism

Scientists at the University of Cologne in Germany have identified a protein that blocks accumulation of the toxic protein aggregates that cause neurodegeneration in Huntington’s disease. Studies by research head David Vilchez, Ph.D.,and colleagues at the University of Cologne’s Cluster of Excellence for Aging Research (CECAD), found that a protein known as UBR5 promotes degradation of the mutant huntingtin protein (HTT) in induced pluripotent stem cells (IPSCs) derived from human Hu