Gift of Protein Regulation Insight Marked “Some Disassembly Required”

Unpack the structure of a protein complex and you can see how it might break apart and become inactive, resulting in potentially adverse consequences. For example, when the protein complex known as protein phosphatase 2A (PP2A) breaks apart, it may fail to deactivate pro-growth proteins and thereby contribute to cancer or neurodegenerative disease.Keeping PP2A intact, or reactivating PP2A that has become inactivated, would seem a good way to preserve health. But how? To help answer that question