Fungal RNAs Targeted by Small Molecule Drugs

Bulging, looping, and twisting, RNA molecules present distinctive three-dimensional shapes, which presumably contain nooks and crannies into which small molecules can nestle, raising expectations that RNA molecules could be “druggable.” Yet few RNA-targeting drugs have been approved to fight human disease. In hopes of developing drugs that could settle into highly structured RNA molecules, scientists based at Yale have devised a new screening technique. This technique, which combines