For Breast Cancer, Targeting Mitochondria Could Be Key

In military strategy, cutting off an enemy’s supply line is an attrition tactic that armies have used since before the time of Genghis Khan. Scientists have often looked toward this approach when fighting disease, especially for cancer. Now, researchers at the National Institutes of Health (NIH) have found that a small-molecule drug called ONC201, originally shown to induce transcription of the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and destroy cancer cells b