Exhausted T Cells Come in Different Flavors

Connoisseurs of exhausted T cells, or Tex cells, may acquire the ability to recognize distinct disease histories. A discrete lineage of Tex cells, it turns out, may emit an epigenetic bouquet particular to a type of disease—a viral infection or cancer, for example. Already, nine distinct types of Tex cells have been identified by researchers at the University of Pennsylvania.In recent years, these researchers have been sensitizing themselves to key features of T-cell exhaustion, which incl