Exercise Pathway That Regulates Muscle Remodeling May Have Implications for Metabolic Diseases

Scientists at the Joslin Diabetes Center have identified a molecular switch that appears to help direct whether we build muscle mass, or develop better aerobic capacity in response to exercise. The protein, c-Jun N-terminal kinase (JNK) is known to be a key regulator of cellular stress and has been associated with inflammatory responses, as well as metabolic diseases such as diabetes. The new findings, reported by a team headed by Sarah Lessard, Ph.D., an assistant investigator at Joslin's secti