Evolution of Engineered Organisms Constrains Bioproduction

Organisms engineered to churn out valuable chemicals tend to slack off when they should be working most productively, after they’ve been introduced to large-scale fermentation vessels. But why? Some feel that large-scale vessels are plagued with physical inefficiencies. Some feel that in large populations of microbes, there are bound to be a few bad apples, phenotypic variants that feel they’ve got the right to coast. Eventually, these variants spoil the whole barrel, err…bior