Epigenetics Linked to Resistance for Anti-Cancer Drug

Scientists at Vanderbilt University say they have discovered a nongenetic cause of resistance to cetuximab, a therapeutic that is used to treat advanced colorectal cancer. The team’s study (“lncRNA MIR100HG-Derived miR-100 and miR-125b Mediate Cetuximab Resistance via Wnt/β-Catenin Signaling”), which is published in Nature Medicine , suggests a novel strategy for overcoming this resistance.“Using whole-exome sequencing and transcriptional profiling, we found that the