Epigenetic Mechanism Found Responsible for Cetuximab Resistance

Scientists at Vanderbilt University say they have discovered a non-genetic cause of resistance to cetuximab, a therapeutic that is used to treat advanced colorectal cancer. The team’s study (“lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling”), which is published in Nature Medicine , suggests a novel strategy for overcoming this resistance.“Using whole-exome sequencing and transcriptional profiling, we found that th