Epigenetic Icebreaker Opens Developmental Passages in T Cells

Genetic regions, like the Arctic’s frozen wastes, may be all but inaccessible, posing a challenge to explorers, who live to map the unknown. Such explorers include researchers at the University of Pennsylvania led by Golnaz Vahedi, Ph.D., an assistant professor of genetics. Dr. Vahedi and her team decided to venture into “locked in” chromatin, where DNA is so tightly coiled that it remains outside the flow, beyond the reach of transcription factors.Well, not all transcription f