Enzyme Identified that Helps Make Cancer Resistant to Cisplatin

Scientists at Winship Cancer Institute of Emory University have identified an enzyme responsible for making tumors and cancer cell lines resistant to cisplatin, along with an experimental drug that targets that enzyme. Their study (“ MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation ”) appears in Cancer Cell.“Platinum-based chemotherapeutics represent a mainstay of cancer therapy, but resistance limits their curative potent