DNA Knot Study Could Help Improve Genome Sequencing Accuracy

Scientists at MIT say they have discovered the factors that determine whether a DNA knot moves along the strand or "jams" in place. The findings could help researchers develop ways to untie DNA knots, which would help improve the accuracy of some genome sequencing technologies, or to promote knot formation. Inducing knot formation could enhance some types of sequencing by slowing down the DNA molecules' passage through the system, according to the MIT team.The study (“Motion of Knots