DNA Enhancer Video Rules Out Hit-and-Run Activity

After a segment of non-protein – coding DNA called an enhancer gets close to its target gene, it tends to stick around, staying attached to the gene’s promoter while the gene’s transcription proceeds. This finding, which comes from an analysis of real-time imaging of an enhancer–promoter interaction, provides evidence against a favored model of gene activation known as the hit-and-run model, which holds that an enhancer need not stay attached to its target gene’s pr