CRISPR/Cas9-Labeled DNA Imaged with DVD Optics

If whole-genome sequencing is like clicking through a DVD frame by frame, and if fluorescence in situ hybridization is like scanning the scene-selection menu, a new technology may offer an intermediate viewing option. This new technology, high-speed atomic force microscopy (HS-AFM) nanomapping, can create images of up to a million base pairs in size. Although HS-AFM nanomapping cannot match the single-base-pair resolution of DNA sequencing, it has the virtue of greater speed. It can fast-forward