CRISPR Improves Red Blood Cell Transfusion Success

Using CRISPR-Cas9– mediated gene editing, researchers based at the U.K.-based NIHR Blood and Transplant Research Unit (NIHR BTRU) in red cell products, BrisSynBio Center, and NHS Blood and Transplant in Bristol created individual cell lines in which specific blood group genes were altered to prevent the expression of blood group proteins that can cause immune reactions. Building on this gene-editing approach, the team then went on to produce cells that combined the deletion of multipl