Cholesterol Halved by CRISPR/Cas9 Base Editing

A naturally occurring loss-of-function mutation associated with reduced blood lipid levels can be introduced by artificial means—a form of genetic engineering called base editing. Whether the mutation occurs by itself or is deliberately introduced, the consequences are the same. Besides lowering the levels of triglycerides and low-density lipoprotein cholesterol in the blood, the mutation provides protection against coronary heart disease.These findings come from mouse research conducted b