Chemo Fails Reversed by Blocking Cancer Cells’ Toxin Pumps

Scientists in Dallas have identified three drug molecules that reverse resistance to chemotherapy in cultures of aggressive, multidrug-resistant (MDR) forms of ovarian, prostate, and breast cancer. The molecules, originally discovered using high-performance supercomputing, act by blocking P-glycoprotein (P-gp), a transmembrane pump that prevents chemotherapy drugs from accumulating in and killing cancer cells. Reporting in Scientific Reports , the South Methodist University (SMU) team, led by Pi