Cellular Messaging Finding Opens Door to New Drug-Delivery Methods

Harvard scientists say a recently discovered cellular messaging mechanism might lead to a new approach for delivering therapeutics to diseased tissues. The team, from the Harvard T.H. Chan School of Public Health, found that a type of extracellular vesicle (EV) known as ARMMs, or arrestin domain-containing protein 1 (ARRDC1)-mediated microvesicles, also carries receptors that allow signaling without direct contact between cells. This capability may make ARMMs uniquely suited to be engineered to