Cause of CRISPR Failure Identified and Reversed

The clustered regularly interspaced short palindromic repeats ( CRISPR ) system has evolved in bacteria as a form of adaptive immune system, which scientists have customized as a versatile tool for gene editing cells in vitro, and potentially in vivo to correct diseases caused by gene mutations. However, CRISPR gene editing using the bacterially derived Cas9 nuclease enzyme isn’t foolproof and the system fails about 15% of the time.Studies by scientists at the University of Illinois (UIC)