CAR-Engineered Blood Stem Cells Offer New Hope for Long-Term HIV Gene Therapy

Researchers in the U.S. have created chimeric antigen receptor (CAR)-engineered hematopoietic stem/progenitor cells (HSPCs), which successfully engrafted in pigtail macaques infected with simian human immunodeficiency virus (SHIV) and generated virus-targeting cytotoxic T cells that destroyed infected cells. Reporting in PLOS Pathogens , the researchers, from the University of California, Los Angeles (UCLA), the Fred Hutchinson Cancer Research Center, and the University of Washington, say that t