Cancer’s Metabolic Off Ramp Found, Restoration of Normal Route Planned

Cancer cell metabolism veers off the normal metabolic path at one place or another, but exactly where hasn’t been clear. It’s not as though metabolic detours are marked with flares or flashing signs. One detour has been identified, however, by scientists based at the University of Wisconsin-Madison. They used a protein interaction assay in a breast cancer cell line and found that a protein called CARM1 chemically modifies a metabolic enzyme called PKM2, changing its function, causing