Cancer Metabolism Link with Breast Cancer Oncogene

Scientists have identified a molecule that connects a biochemical pathway used by cancer cells to generate energy and regulates an oncogene that drives the progression of breast cancer and other tumor types. The studies, by a team at Baylor College of Medicine and Roswell Park Comprehensive Cancer Center, showed that PFKFB4, an enzyme in the Warburg pathway, activates an oncogene called SRC-3. The findings throw new light on the long-recognized phenomenon of the Warburg effect—by which can