Cancer-Initiating Cells Stay “Stemmy” via CDK1/Sox2 Interaction

Extreme normality in superficial or seemingly inconsequential matters can be a sign that something is deeply wrong. This thought may have occurred to scientists at the University of Colorado (CU) Cancer Center when they began looking at a population of cancer cells that, unlike most cancer cells, avoids downregulating MHC Class I molecules. Cancer cells tend to deemphasize these molecules because they can display abnormal proteins and attract the immune system’s attention. Cancer cells tha