Cancer Immunotherapy Resistance Related to Chromatin Remodeling Genes

Despite it’s encouraging successes, cancer immunotherapy mostly fails against cancer. If cancer immunotherapy is to succeed more widely, its failures will have to be scrutinized for mechanisms of resistance—mechanisms that can then be recognized as drug targets.One mechanism of cancer resistance has been uncovered by two recent studies—one a preclinical study, the other a clinical study of patients with kidney cancer. Both studies converged on the chromatin remodeling complex.