Blocking Single Enzyme in Mice Kills Tumors without Toxicity

Scientists headed by team at the Karolinska Institutet in Sweden have identified a new approach to cancer therapy that involves blocking a single enzyme that plays a key role in how tumors respond to oxidative stress. Elias Arnér, Ph.D., and colleagues identified highly specific inhibitors of the selenium-containing TXN reductase 1 (TXNRD1) that were effective against multiple tumor types in mice, without showing any obvious toxicity to mitochondria or other cellular systems. Based on the