Autism-Like Social Deficits Reversed by Epigenetic Drug

A chromatin-loosening drug already approved as a cancer therapeutic may have another application—reversing the social deficits associated with autism spectrum disorder (ASD). If chromatin is packed too tightly, it can entomb genes, preventing their expression by closing them off from the cell's transcriptional machinery.Effectively disinterring genes, and thereby allowing them to be expressed again, is a strategy that has been pursued in the development of anticancer drugs such as romideps