Approved Anti-Cancer Drugs Reveal New Target: Non-Coding RNAs

Scientists at The Scripps Research Institute and the California Institute for Biomedical Research (CALIBR) have found that some types of small-molecule drugs, including marketed anticancer drugs, may work in part by binding to disease-related noncoding RNAs. Their discovery could open up new avenues of research for developing small-molecule drugs against what are otherwise considered undruggable diseases, including amyotrophic lateral sclerosis (ALS), cystic fibrosis, muscular dystrophy, and som