Alzheimer’s Multigene Test Better Prognosticator Than APOE E4

Scientists say that a new test, which combines the effects of more than two dozen genetic variants linked to a slight risk of Alzheimer's by themselves, is better than testing only for APOE E4 in predicting which cognitively normal older adults will eventually develop Alzheimer's dementia.The polygenic hazard score (PHS) provides risk estimates for the 85% to 90% of individuals who do not carry at least one copy of APOE E4 but still have some combination of other genetic variants that put them a