Alcohol Addiction Therapy Resensitizes Resistant NSCLC to Chemotherapy

Scientists in Ireland have shown how a drug that has been prescribed for 60 years to treat alcohol addiction can also resensitize treatment-resistant non-small-cell lung cancer (NSCLC) to chemotherapy. The drug, disulfiram—also known as Antabuse—blocks aldehyde dehydrogenase (ALDH), which is a key enzyme involved in metabolizing alcohol, but is also involved in early stem cell differentiation. A team led by Martin P. Barr, Ph.D., at the Trinity Translational Medicine Institute, St. J