Aggressive Brain Cancer Can Be Driven by Tumor Suppressor

AMP-activated protein kinase (AMPK) is involved in regulating cell metabolism and is largely thought to play a suppressive role in cancer. Research by scientists at the Cincinnati Children’s Cancer and Blood Diseases Institute has now indicated that the protein may represent a key driver of aggressive brain cancers, including glioblastoma (GBM). Their studies showed that blocking AMPK reduced the growth of GBM stem cells (GSCs) transplanted into the cerebral cortex of experimental mice, le