Advanced Computational Methods May Lead to New Peptide Drugs

Researchers say they have used computational techniques that could lead to the development of novel, small macrocyclic peptide-based drugs. Peptides such as cyclosporine are stable like small molecules and selective like antibodies, they add.The scientists explain that naturally occurring peptides that might serve as scaffolds are few and often fail to perform as expected when repurposed. As a result, the traditional approach has been to screen large, randomly generated compound libraries to fin